Reaction Technology
Over the last forty years, our company has built up a comprehensive capability & expertise covering a wide range of reaction technology, particularly focusing on chemocatalysis and biocatalysis. Our reaction technology is supported and reinforced by a continuous programme of investment in research and development, leading to significant process innovation and technical improvements.
The application of biocatalysts in the pharmaceutical and fine chemical industries continues to grow as it moves from the domain of specialised technology to mainstream methodology. Arran is the industry leader in the development and scaleup of biocatalysis technology and has approximately ten enzymatic processes operating at commercial scale. We have significantly invested in this area to secure the supply of selectAZymeTM biocatalysts for clients’ manufacturing projects.
Reactions routinely scaled-up and used in bulk manufacture of fine chemicals at Arran Chemical Company include:
- Alkylation
- Aminoalkylation
- Asymmetric Synthesis
- Biotransformations
- Base Catalysis
- Transfer Hydrogenation
- Condensations
- Dealkylation
- Dieckmann Condensation
- Diels Alder Reaction
- Enzymatic Resolution
- Flow Chemistry
- Enzyme Immobilisation
- Heck Reaction
- Flow Hydrogenation
- Hydrolase Bioresolutions
- Grignard Reactions
- KRED Bioreductions
- Leuckart Reaction
- Methylations
- Michael Reaction
- Mannich Reaction
- Nitrilase Reactions
- Optical Resolution
- Organolithium Chemistry
- Organometallic Chemistry
- Organosilicon Chemistry
- Oxidation
- P450 Biooxidation
- Ritter Reaction
- Stereoselective Reactions
- Suspension Polymerisation
- Transaminase Bioreactions
In addition, we work with the following specialist reagents:
- Dimethyl Carbonate for Methylation
- Hexyl Lithium, LAH, LDA, LiHMDS, Lithium Metal
- Peracetic Acid for Oxidations
- cis-1-Aminoindanol Derivatives for Asymmetric Reactions
- Lithium and Alkylithium Reactions
- Specialised Monomers Based on Acrylate and Silicon Chemistry
- Catalysts for Asymmetric Synthesis
- Precious Metal Catalysts Pd, Ru, Os
- Girgnard Reactions
- Transition Metal Complexes
With well-integrated laboratory and production facilities on one site, we can work from gram scale in our development laboratories, through kilo lab and pilot plant, to multi-tonne scale in our main production plant.
Our range of equipment enables us to handle solid and liquid products, with a reaction temperature range from -40°C to +200°C, and the routine use of low pressure (vacuum) distillation.
