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Reaction Technology

Over the last thirty years, our company has built up a comprehensive capability & expertise covering a wide range of reaction technology, particularly focusing on chemocatalysis and biocatalysis. Our reaction technology is supported and reinforced by a continuous programme of investment in research and development, leading to significant process innovation and technical improvements.

The application of biocatalysts in the pharmaceutical and fine chemical industries continues to grow as it moves from the domain of specialised technology to mainstream methodology. This movement has been facilitated by the increasing commercial ‘off-the-shelf’ availability of biocatalysts. We have significantly invested in this area to secure the supply of selectAZyme™ biocatalysts for clients’ manufacturing projects.

Reactions routinely scaled-up and used in bulk manufacture of fine chemicals at Arran Chemical Company include:
  • Alkylation
  • Aminoalkylation
  • Asymmetric Synthesis
  • Biotransformations
  • Base Catalysis
  • Transfer Hydrogenation
  • Condensations
  • Dealkylation
  • Dieckmann Condensation
  • Diels Alder Reaction
  • Enzymatic Resolution
  • Enzyme Immobilisation
  • Heck Reaction
  • Hydrogenation
  • Hydrolase Bioresolutions
  • Grignard Reactions
  • KRED Bioreductions
  • Reductions
  • Leuckart Reaction
  • Methylations
  • Michael Reaction
  • Mannich Reaction
  • Nitrilase Reactions
  • Optical Resolution
  • Organolithium Chemistry
  • Organometallic Chemistry
  • Organosilicon Chemistry
  • Oxidation
  • P450 Biooxidation
  • Ritter Reaction
  • Stereoselective Reactions
  • Suspension Polymerisation
  • Transaminase Bioreactions
In addition, we work with the following specialist reagents:
  • Dimethyl Carbonate for Methylation
  • Hexyl Lithium, LAH, LDA, LiHMDS, Lithium Metal
  • Peracetic Acid for Oxidations
  • cis-1-Aminoindanol Derivatives for Asymmetric Reactions
  • Lithium and Alkylithium Reactions
  • Specialised Monomers Based on Acrylate and Silicon Chemistry
  • Catalysts for Asymmetric Synthesis
  • Precious Metal Catalysts Pd, Ru, Os
  • Girgnard Reactions
  • Transition Metal Complexes

With well-integrated laboratory and production facilities on one site, we can work from gram scale in our development laboratories, through kilo lab and pilot plant, to multi-ton scale in our main production plant.
Our range of equipment enables us to handle solid and liquid products, with a reaction temperature range from -50°C to +200°C, and the routine use of low pressure (vacuum) distillation.

Get in touch
The application of biocatalysts in the pharmaceutical and fine chemical industries continues to grow as it moves from the domain of specialised technology to mainstream methodology.
Tom Moody, VP Technology Development & Commercialisation

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